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Amiodarone is a class III antiarrhythmic that blocks potassium channels. In acute therapy, most of its effects are due to its action as a sodium channel blocker, thereby reducing automaticity and conduction velocity in the ventricles.Amiodarone is used to treat life-threatening heart rhythm problems called ventricular arrhythmias. This medicine is used in patients who have already been treated with other medicines that did not work well.Amiodarone (Cordarone) is used to treat and prevent an irregular heartbeat. It slows down nerve activity in the heart and relaxes an overactive heart.
What does the drug amiodarone do?
Amiodarone is used to treat life-threatening heart rhythm problems called ventricular arrhythmias. This medicine is used in patients who have already been treated with other medicines that did not work well.
What does amiodarone do to the heart?
Amiodarone (Cordarone) is used to treat and prevent an irregular heartbeat. It slows down nerve activity in the heart and relaxes an overactive heart.
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How does amiodarone stop ventricular fibrillation?
The major effect of chronic amiodarone therapy is an inhibition of outward potassium currents (Vaughan-Williams class III effect) resulting in a prolongation of action potential duration (APD), not only in atrial and ventricular muscles but also in the SA and AV nodes.
What does amiodarone do to BP?
Does amiodarone affect the blood pressure? Amiodarone can also decrease blood pressure, slow heart rate, and—at higher doses or with long-term use—even cause arrhythmias of its own. This becomes more prominent when given in combination with medications used to treat hypertension and cardiac disorders.
Does amiodarone slow heart rate?
In addition to its antiarrhythmic action, amiodarone slows the sinus heart rate.
Is amiodarone a beta blocker?
Amiodarone is a coronary and peripheral vasodilator (1). Metoprolol is a selective beta1-blocker and exerts a slight vasoconstrictor effect on coronary arteries due to its lack of beta2 stimulation (1).
What are the most common side effects of amiodarone?
- Cough.
- dizziness, lightheadedness, or fainting.
- fever (slight)
- numbness or tingling in the fingers or toes.
- painful breathing.
- sensitivity of the skin to sunlight.
- trembling or shaking of the hands.
- trouble with walking.
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Is amiodarone a calcium channel blocker?
Antiarrhythmic agent amiodarone possesses calcium channel blocker properties.
What are the serious side effects of amiodarone?
Amiodarone should only be used if you have a life threatening arrhythmia or irregular heart rate. This medication has the risk of serious side effects. These include serious lung problems, liver problems, and a worsening of your irregular heart rate. These problems can be fatal.
Is amiodarone a rate or rhythm control?
Intravenous amiodarone can be useful for acute rate control with minimal hemodynamic effects when administered slowly in severely ill patients with AF or other atrial tachyarrhythmias.
What is the first line treatment for ventricular fibrillation?
If the patient remains in ventricular fibrillation, pharmacological treatment should begin. Epinephrine is the first drug given and may be repeated every 3 to 5 minutes. If epinephrine is not effective, the next medication in the algorithm is amiodarone 300 mg.
Is amiodarone a vasopressor or vasodilator?
Objective: Amiodarone, a class III antiarrhythmic agent, is a potent coronary vasodilator.
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Why does amiodarone cause hypotension?
In the acute setting, amiodarone can cause hypotension due to vasodilation and depression of myocardial contractility; this may be partly due to the solvent, polysorbate 80 or benzyl alcohol, used to assist in dissolving the drug [6–8].
Does amiodarone lower potassium levels?
It seems reasonable to consider the combination of both as dangerous when we take into account that the majority of patients cited as having amiodarone-induced torsade de pointes had also potassium depletion.
Can you take amiodarone and metoprolol together?
Using amiodarone together with metoprolol may lead to increased side effects. Contact your doctor if you experience a reduced heart rate, dizziness, fainting, or headaches. You may need a dose adjustment or need your blood pressure checked more often if you use both medications.
What medications should not be taken with amiodarone?
Amiodarone can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include clopidogrel, macitentan, phenytoin, certain “statin” drugs (atorvastatin, lovastatin), trazodone, warfarin, among others.
What should be avoided while taking amiodarone?
You should avoid consuming grapefruits and grapefruit juice while taking amiodarone. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Grapefruit can raise the levels of amiodarone in your body and lead to dangerous side effects.
What is the best time of day to take amiodarone?
Try to take your doses of amiodarone at the same times each day, as this will help you to remember to take them regularly. You can take amiodarone either before or after meals.
What is the best drug for atrial fibrillation?
Heart rate controlling medicines, such as beta-blockers that include Coreg (Carvedilol) and Lopressor and Toprol (Metoprolol), is the best way to treat AFib. These medications can control or slow the rapid heart rate so that the heart can function in a better way.
What is a substitute drug for amiodarone?
Dronedarone has been viewed as a potential therapeutic alternative for amiodarone because of a lower risk for pulmonary, thyroid, and dermatologic adverse effects. Compared with amiodarone, dronedarone has poor bioavailability and a shorter terminal disposition half-life, which dictates a twice-daily dosing regimen.
What class antiarrhythmic is amiodarone?
Although amiodarone is considered a class III anti-arrhythmic agent, it also has class I, II, IV actions, making it a unique and effective anti-arrhythmic agent.
Is amiodarone safe for the elderly?
Due to its long-term side effects, oral amiodarone as a rate control agent is avoided in younger patients but should be considered in the elderly, especially if they are refractory to other medications. It has less frequent side effects in terms of pro-arrhythmia, bradycardia or hypotension.
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How long can you safely take amiodarone?
Toxicity can occur at any time during the course of treatment. Those at the greatest risk are patients who have taken a daily dose of 400 mg or more for more than two months, or a lower dose, commonly 200 mg daily, for more than two years.
Can amiodarone be stopped suddenly?
Do not stop taking amiodarone without talking to your doctor. You may need to be closely monitored or even hospitalized when you stop taking amiodarone. Amiodarone may remain in your body for some time after you stop taking it, so your doctor will watch you carefully during this time.
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